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Flibanseriini kehitettiin alun perin masennuslääkkeeksi [3] [4], mutta tutkimukset osoittivat, ettei se ole tässä indikaatiossa lumelääkettä parempi ja sen käyttöä alettiin tutkimaan HSDD:n。

Flibanseriini toimii prefrontaalisella aivoalueella serotoniini 1A -reseptorin agonistina ja 2A-reseptorin antagonistina. flibanseriiniSeurauksena on dopamiinin ja noradrenaliinin lisääntyminen ja serotoniinin väheneminen aivojen。

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